Wnt Coreceptor <i>Lrp5</i> Is a Driver of Idiopathic Pulmonary Fibrosis

Abstract

We show that the Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis in mice and a marker of disease progression and severity in humans with IPF. Evidence that TGF-β signaling can override a loss in Lrp5 has implications for patient selection and timing of Wnt pathway inhibitors in lung fibrosis.