Homozygosity of the <i>T</i> Allele of the 46 C→T Polymorphism in the <i>F12</i> Gene Is a Risk Factor for Ischemic Stroke in the Spanish Population

Abstract

This study suggests that the 46 C-->T polymorphism is a genetic risk factor for IS in the Spanish population. In addition, our results confirm that the use of genetic linkage studies along with a case-control association study is an extremely valuable approach for identifying DNA variants that affect complex diseases.