Triglyceride-lowering Effect of Dietary Vitamin E in Streptozocin-induced Diabetic Rats: Increased Lipoprotein Lipase Activity in Livers of Diabetic Rats Fed High Dietary Vitamin E

Abstract

High vitamin E supplementation in the diets of streptozocin-induced diabetic rats eliminates accumulation of lipid peroxides in the plasma and the liver, returns the plasma triglycerides toward normal levels, and increases the activity of lipoprotein lipase. Vitamin E has no effect on the levels of insulin or glucose. These findings suggest that vitamin E increases the total hepatic triglyceride lipase activity by increasing the lipoprotein lipase activity possibly by protecting the membrane-bound lipase against peroxidative damage.