Association of Levels of Fasting Glucose and Insulin With Rare Variants at the Chromosome 11p11.2- <i>MADD</i> Locus

Abstract

Sequencing at 11p11.2-NR1H3 identified rare variation associated with FI. One variant, chr11:47227430, seems to be functional, with the rare A allele reducing transcription factor FOXA1 binding and FOXA1-dependent transcriptional activity.