1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations · Full text

Recognition Site Probe, Molecular Regulation, Genetics +18

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

Aruna Kode, R. Saravanan, Samuel Caito et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2007 · 443 citations

Inflammation, Reductive Stress, Redox Signaling +15

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

Chenhui Yang, Xiangjian Zhang, Hongguang Fan et al. · Brain Research · 2009 · 438 citations

Cell Death, Cerebral Vascular Regulation, Oxidative Stress +16

Mitochondrial Generation of Reactive Oxygen Species After Brain Ischemia in the Rat

Claude A. Piantadosi, Jing Zhang · Stroke · 1996 · 395 citations

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

R Li, Mario A. Bianchet, Paul Talalay et al. · Proceedings of the National Academy of Sciences · 1995 · 334 citations · Full text

Obligatory Nad, Reductive Stress, Dt Diaphorase +14