Infection and Immunity · 2004 · 220 citations · 20 references
InflammationVitro InfectionCytokinePulmonary TuberculosisMedical MicrobiologyTh2 Polarized ImmunityPathogenesisImmune RegulationImmunologyTuberculosisExtracted LipidsInnate ImmunityMicrobiologyImmune MediatorImmune SystemMedicineClinical MicrobiologyPhagocyte
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.
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Claudia Manca, Liana Tsenova, Amy Bergtold et al. · Proceedings of the National Academy of Sciences · 2001 · 596 citations · Full text