Concepedia

A Highly Convergent Synthesis of 2‐Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors

Hongxing Yan, Jeffrey K. Kerns, Qi Jin, Chongjie Zhu, Mary S. Barnette, James F. Callahan, Douglas W.P. Hay, Larry J. Jolivette, Mark A. Luttmann, Henry M. Sarau,

Synthetic Communications · 2005 · 13 citations · 20 references

DOI

Concepts

Abstract

Abstract A novel and highly convergent synthesis leading to 2‐phenyl‐quinolines has been developed. As demonstrated in the preparation of 6‐fluoro‐3‐(3‐oxo‐piperazin‐1‐ylmethyl)‐2‐phenyl‐quinoline‐4‐carboxylic acid [(S)‐1‐cyclohexyl‐ethyl]‐amide (8), the method provides fascile access to this class of analogues via the common intermediate 7.

References

20

Iron-Catalyzed Cross-Coupling Reactions

Alois Fürstner, Andreas Leitner, Marı́a Méndez et al. · Journal of the American Chemical Society · 2002 · 820 citations

, , +14

Highly Active, Air-Stable Versatile Palladium Catalysts for the C−C, C−N, and C−S Bond Formations via Cross-Coupling Reactions of Aryl Chlorides

George Y. Li, Gang Zheng, Andrew F. Noonan · The Journal of Organic Chemistry · 2001 · 315 citations

, , +16

Synthesis of Biaryls via a Nickel(0)-Catalyzed Cross-Coupling Reaction of Chloroarenes with Arylboronic Acids

Syun Saito, Saori Oh-tani, Norio Miyaura · The Journal of Organic Chemistry · 1997 · 246 citations

, , +16

Highly Active, Air-Stable Palladium Catalysts for the C−C and C−S Bond-Forming Reactions of Vinyl and Aryl Chlorides:  Use of Commercially Available [(<i>t</i>-Bu)<sub>2</sub>P(OH)]<sub>2</sub>PdCl<sub>2</sub>, [(<i>t</i>-Bu)<sub>2</sub>P(OH)PdCl<sub>2</sub>]<sub>2</sub>, and [[(<i>t</i>-Bu)<sub>2</sub>PO···H···OP(<i>t</i>-Bu)<sub>2</sub>]PdCl]<sub>2</sub> as Catalysts

George Y. Li · The Journal of Organic Chemistry · 2002 · 196 citations

, , +17

Synthesis of Biaryls via Cross-Coupling Reaction of Arylboronic Acids with Aryl Chlorides Catalyzed by NiCl2/Triphenylphosphine Complexes

Kaoru Inada, Norio Miyaura · Tetrahedron · 2000 · 114 citations

, , +9