Spontaneous and Induced Release of Prostaglandins, Interleukin (IL)‐1β, IL‐6, and Tumor Necrosis Factor‐α by Placental Tissue from Normal and Preeclamptic Pregnancies

Abstract

The overproduction of TNF-alpha may be related not only to the effect of a stimulant like IL-1beta, but mainly to the lack of mechanisms down-regulating the production of TNF-alpha.