Concepedia

INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN’S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURES

Bernard J. Komoroski, Shimin Zhang, Hongbo Cai, J. Matthew Hutzler, Reginald F. Frye, Timothy S. Tracy, Stephen C. Strom, Thomas Lehmann, C.Y.W. ANG, Yan Cui,

Drug Metabolism and Disposition · 2004 · 180 citations · 20 references

DOI

Concepts

References

20

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

, , +17

A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions

Roberta J. Pohl, James R. Fouts · Analytical Biochemistry · 1980 · 823 citations

, , +11

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

Daniel Dürr · Clinical Pharmacology & Therapeutics · 2000 · 587 citations

, , +15

Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression

R. Scott Obach · Journal of Pharmacology and Experimental Therapeutics · 2000 · 400 citations

, , +17

Effect of grapefruit juice on digoxin pharmacokinetics in humans

Laurent Becquemont, Céline Verstuyft, Reinhold Kerb et al. · Clinical Pharmacology & Therapeutics · 2001 · 389 citations

, , +17