SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors

Importance of Ribonucleotide Availability to Proliferating T-lymphocytes from Healthy Humans

Lynette D. Fairbanks, Margarita Bofill, Katarzyna Rückemann-Dziurdzińska et al. · Journal of Biological Chemistry · 1995 · 314 citations · Full text

Life Sciences, Biochemistry, Immunology +13

The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

June P. Davis, Gary A. Cain, William J. Pitts et al. · Biochemistry · 1996 · 294 citations

Medicine, Biochemistry, Pharmacology +13

Detection of human white cell proliferative responses by immunoenzymatic measurement of bromodeoxyuridine uptake

J.‐P. Magaud, Ian L. Sargent, David Y. Mason · Journal of Immunological Methods · 1988 · 150 citations

Life Sciences, Immunology, Cellular Immunology +3

T-lymphocytes from AIDS Patients Are Unable to Synthesize Ribonucleotides de Novo in Response to Mitogenic Stimulation

Margarita Bofill, Lynette D. Fairbanks, Katarzyna Rückemann-Dziurdzińska et al. · Journal of Biological Chemistry · 1995 · 119 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

Johann Leban, Wael Saeb, Gabriel Garcia et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17