Betulinic Acid: Isolation from<i>Triphyophyllum peltatum</i>and<i>Ancistrocladus heyneanus</i>, Antimalarial Activity, and Crystal Structure of the Benzyl Ester*

Gerhard Bringmann, Wael Saeb, Laurent Assi, +4

Planta Medica

Crystal StructureBiosynthesisBioorganic ChemistryBiochemistryAntiparasitic Agent +13

A Photometric Screening Method for Dimeric Naphthylisoquinoline Alkaloids and Complete On-Line Structural Elucidation of a Dimer in Crude Plant Extracts, by the LC−MS/LC−NMR/LC−CD Triad

Gerhard Bringmann, Michael Wohlfarth, Heiko Rischer, +5

Analytical Chemistry

Ancistrolikokine D, a 5,8′-coupled naphthylisoquinoline alkaloid, and related natural products from Ancistrocladus likoko

Gerhard Bringmann, Wael Saeb, Markus Rückert, +4

Phytochemistry

Ancistrolikokine DBioorganic ChemistryBiochemistryNatural SciencesOrganic Chemistry +6

Directed joint total synthesis of the three naphthylisoquinoline alkaloids dioncolactone A, dioncopeltine A, and 5′-O-demethyldioncophylline A

Gerhard Bringmann, Wael Saeb, Martin Rübenacker

Tetrahedron

EngineeringDioncopeltine ADiversity-oriented SynthesisOrganic ChemistryJoint Total Synthesis +4

Computer-Aided Design of Agents That Inhibit the <i>cep</i> Quorum-Sensing System of <i>Burkholderia cenocepacia</i>

Manuela Köthe, B. Krämer, Wael Saeb, +3

Antimicrobial Agents and Chemotherapy

BiologyHealth SciencesAntibioticsMedicineImportant Pathogens +13

The absolute configuration of (+)-isoshinanolone and in situ LC–CD analysis of its stereoisomers from crude extracts

Gerhard Bringmann, Kim Messer, Wael Saeb, +2

Phytochemistry

Absolute ConfigurationEngineeringBiochemistryCrude ExtractsMedicine +9

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Stefan Tasler, Oliver Müller, Tanja Wieber, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineRational Drug DesignKinase InhibitorsDrug Development +3

5′-O-demethyldioncophylline A, a new antimalarial alkaloid from triphyophyllum peltatum1Part 111 in the series “Acetogenic Isoquinoline Alkaloids”. For Part 110, see Ref.[1].1

Gerhard Bringmann, Wael Saeb, Ralf God, +7

Phytochemistry

Part 110Bioorganic ChemistryAntiparasitic AgentMedicineHerbal Medicine +6

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

Johann Leban, Wael Saeb, Gabriel Garcia, +2

Bioorganic & Medicinal Chemistry Letters

Dhodh InhibitorsMedicinal ChemistryDrug TargetBiochemistryQsar Refinement +9

Jozimine A (‘dimeric’ dioncophylline A), a non-natural michellamine analog with high antimalarial activity

Gerhard Bringmann, Wael Saeb, D. Koppler, +1

Tetrahedron

Molecular PharmacologyMedicinal ChemistryNon-natural Michellamine AnalogHigh Antimalarial ActivityMedicine +5