Molecular Cancer · 2010 · 17 citations · 48 references
The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression. MCT-1 oncogenicity can overcome p53 function that persistently advances the tumor development.
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WAF1, a potential mediator of p53 tumor suppression
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Mdm2 promotes the rapid degradation of p53
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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