Chemical Communications · 2014 · 69 citations · 16 references
MedicineChemical BiologyOncologyMolecular ImagingMolecular OncologyMonoclonal AntibodiesAntibody DiscoveryMonoclonal Antibody TherapyTargeted Cancer TherapyTargeted Imaging AgentsTherapeutic Monoclonal AntibodiesTumor Receptor ImagingAntibody-based Imaging AgentsCetuximab TherapyEpidermal Growth Factor Receptor ImagingIn Vivo ImagingInverse Electron-demand Diels-alder ReactionInverse-electron-demand Diels-alder ReactionsPreclinical Cancer ImagingTargeted Molecular Imaging Agents
Herein, we describe a fast and robust method for achieving (68)Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.
16
Chemical remodelling of cell surfaces in living animals
Jennifer A. Prescher, Danielle H. Dube, Carolyn R. Bertozzi · Nature · 2004 · 839 citations
Life Sciences, Biology, Cell Biology +16