Single-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsis

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

Peter Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology · 1977 · 11.7K citations

Nucleic Acid Chemistry, High Specific Activity, Biochemistry +8

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 3.9K citations

Engineering, Immunology, Synthetic Biology +6

Somatic generation of antibody diversity.

PubMed · 1976 · 3.3K citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Immunogenetics, Lymphocyte Development, Immune Cell Development +7

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

Marjorie A. Oettinger, David G. Schatz, Carolyn Gorka et al. · Science · 1990 · 1.4K citations

Lymphocyte Development, Adaptive Immune System, Genetics +22