Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients

Comparison of Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis

Marc I. Chimowitz, Michael Lynn, Harriet Howlett-Smith et al. · New England Journal of Medicine · 2005 · 1.7K citations · Full text

Medicine, Pharmacotherapy, Surgery +12

Effect of <i>VKORC1</i> Haplotypes on Transcriptional Regulation and Warfarin Dose

Mark J. Rieder, Alex P. Reiner, Brian F. Gage et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

Life Sciences, Genetics, Pharmacology +14

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations

Medicine, Genetics, Molecular Genetics +12

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

Mitchell K. Higashi · JAMA · 2002 · 1.1K citations

Medicine, Genetics, Pharmacology +17

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Elizabeth Sconce, Tayyaba Khan, Hilary Wynne et al. · Blood · 2005 · 947 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17