A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors - Concepedia

Concepedia

Publication | Closed Access

A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors

90

Citations

37

References

2007

Year

Marwan Fakih, Donald L. Trump, Josephia R. Muindi, Jennifer D. Black, Ronald J. Bernardi, Patrick J. Creaven, J. D. Schwartz, Michael G. Brattain, Alan D. Hutson, Renee A. French,

Clinical Cancer Research

Abstract

High doses of weekly i.v. calcitriol can be administered safely in combination with gefitinib. Calcitriol concentrations achieved at the MTD 74 mug calcitriol exceed in vivo concentrations associated with antitumor activity in preclinical models.

References

	Year	Citations

Page 1