Journal of Nutrition · 2005 · 580 citations · 78 references
MedicineEndocrinologyNutritional SciencesBone MetabolismHuman NutritionMineral MetabolismBone DisordersBone HealthBone Metabolism DisordersOsteoporosisVitamin DVitamin D DeficiencyBone Matrix BiochemistryCalcium Deficiency In ChildrenPediatric Vitamin D DeficiencySerum 25-Hydroxyvitamin D StatusVitamin D Deficiency-related HyperparathyroidismVitamin D Effects On BoneVitamin D InsufficiencyVitamin D Physiology
Vitamin D deficiency, now an epidemic in the U.S. due to inadequate sun exposure, causes rickets in children, osteoporosis and osteomalacia in adults, muscle weakness, and is linked to type I diabetes, multiple sclerosis, rheumatoid arthritis, hypertension, cardiovascular disease, and cancers.
Vitamin D deficiency is now recognized as an epidemic in the United States. The major source of vitamin D for both children and adults is from sensible sun exposure. In the absence of sun exposure 1000 IU of cholecalciferol is required daily for both children and adults. Vitamin D deficiency causes poor mineralization of the collagen matrix in young children's bones leading to growth retardation and bone deformities known as rickets. In adults, vitamin D deficiency induces secondary hyperparathyroidism, which causes a loss of matrix and minerals, thus increasing the risk of osteoporosis and fractures. In addition, the poor mineralization of newly laid down bone matrix in adult bone results in the painful bone disease of osteomalacia. Vitamin D deficiency causes muscle weakness, increasing the risk of falling and fractures. Vitamin D deficiency also has other serious consequences on overall health and well-being. There is mounting scientific evidence that implicates vitamin D deficiency with an increased risk of type I diabetes, multiple sclerosis, rheumatoid arthritis, hypertension, cardiovascular heart disease, and many common deadly cancers. Vigilance of one's vitamin D status by the yearly measurement of 25-hydroxyvitamin D should be part of an annual physical examination.
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Decreased bioavailability of vitamin D in obesity
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