Human cartilage gp‐39+,CD16+ monocytes in peripheral blood and synovium: Correlation with joint destruction in rheumatoid arthritis

Abstract

CD16+ monocytes, a cellular source of HC gp-39 in vivo, are overrepresented in both RA peripheral blood and synovial tissue. The presence of HC gp-39+ cells in RA synovium is correlated with the degree of joint destruction. These data support a role of these cells in the local autoimmune response that leads to chronic inflammation and joint destruction.