Synthesis of (1′, 2′-trans)-3-phenyl-1-[2′-(N-pyrrolidinyl)cyclohexyl]-pyrrolid-2-ones as κ-selective opiates

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

Philip F. VonVoigtlander, Robert A. Lahti, James H. Ludens · Journal of Pharmacology and Experimental Therapeutics · 1983 · 816 citations

Medicine, Medicinal Chemistry, Pharmacology +16

A kappa opioid effect: increased urination in the rat.

J. David Leander · Journal of Pharmacology and Experimental Therapeutics · 1983 · 226 citations

Medicine, Neuroscience, Pharmacology +16

Naloxone-inaccessible sigma receptor in rat central nervous system.

S. William Tam · Proceedings of the National Academy of Sciences · 1983 · 218 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Properties of a selective kappa agonist, U-50,488H

Robert A. Lahti, Philip F. VonVoigtlander, Craig L. Barsuhn · Life Sciences · 1982 · 198 citations

Medicine, Pharmacology, Cell Signaling +8

Benzeneacetamide amines: structurally novel non-m.mu. opioids

Jacob Szmuszkovicz, P. F. VON VOIGTLANDER · Journal of Medicinal Chemistry · 1982 · 155 citations

Medicine, Medicinal Chemistry, Pharmacology +6