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Efficient Copper-Free PdCl<sub>2</sub>(PCy<sub>3</sub>)<sub>2</sub>-Catalyzed Sonogashira Coupling of Aryl Chlorides with Terminal Alkynes
169
Citations
6
References
2006
Year
Materials ScienceInorganic ChemistryTerminal AlkynesCross-coupling ReactionAryl ChloridesEngineeringSonogashira CouplingOrganic ChemistryOrganometallic CatalysisCatalysisHomogeneous CatalysisChemistryCopper-free ConditionsElectron-deficient Aryl Chlorides
Under copper-free conditions and with Cs2CO3 as a base, PdCl2(PCy3)2 showed high catalytic activity for cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes in DMSO at 100−120 °C affording internal arylated alkynes in good to excellent yields.
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