Publication | Closed Access
A Versatile Catalyst for the Sonogashira Coupling of Aryl Chlorides
191
Citations
33
References
2003
Year
Chemical EngineeringVersatile CatalystAryl ChloridesAryl AlkynesEngineeringCross-coupling ReactionSonogashira CouplingOrganic ChemistryOrganometallic CatalysisCatalysisChemistryAsymmetric CatalysisCatalytic Synthesis
Aryl chlorides are suitable substrates for the Sonogashira coupling! By using the versatile catalyst system Na2[PdCl4]/PR3/CuI (PR3=(1-Ad)2PBn, PtBu3), the Sonogashira coupling [Eq. (a)] of aryl chlorides with alkynes generates excellent yields of the corresponding disubstituted aryl alkynes.
| Year | Citations | |
|---|---|---|
Page 1
Page 1