Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith et al. · Nature · 2007 · 3.1K citations · Full text

Somatic Mutation, Somatic Variant, Genetics +2

Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Louis J. Lombardo, Francis Y. Lee, Ping Chen et al. · Journal of Medicinal Chemistry · 2004 · 1.3K citations · Full text

Drug Target, Preclinical Assays, Pharmacotherapy +19

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

Moosa Mohammadi, Gerald McMahon, Li Sun et al. · Science · 1997 · 1.1K citations · Full text

Molecular Biology, Cell Growth, Signaling Pathway +17

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

Luca Pellegrini, David F. Burke, F. von Delft et al. · Nature · 2000 · 704 citations

Crystal Structure, Molecular Modeling, Protein X-ray Crystallography +6

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

Egle Avizienyte, Anne W. Wyke, Robert J. Jones et al. · Nature Cell Biology · 2002 · 352 citations

Signal Transduction, Signaling Pathway, Medicine +11