Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

Timothy M. Browder, Catherine Butterfield, Birgit M. Kräling et al. · PubMed · 2000 · 1.6K citations

Medicine, Oncology, Pharmacology +16

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17

Cytochrome <i>P</i>450 enzymes: Novel options for cancer therapeutics

Morag McFadyen, William T. Melvin, Graeme I. Murray · Molecular Cancer Therapeutics · 2004 · 243 citations

Medicine, Oncology, Pharmacology +16

Angiostatin suppresses malignant glioma growth in vivo.

Matthias Kirsch, Jon Strasser, Ricardo Allende et al. · PubMed · 1998 · 186 citations

Medicine, Oncology, Pharmacology +15

Expression of cytochromes P450 in human breast tissue and tumors.

Zhen Huang, Michael J. Fasco, Helen L. Figge et al. · Drug Metabolism and Disposition · 1996 · 184 citations

Life Sciences, Biochemistry, Oncology +5