Concepedia

Rho-GDP dissociation inhibitor alpha downregulated by low shear stress promotes vascular smooth muscle cell migration and apoptosis: a proteomic analysis

Ying‐Xin Qi, Mingjuan Qu, Ding-Kun Long, Bo Liu, Qing‐Ping Yao, Shu Chien, Zong‐Lai Jiang

Cardiovascular Research · 2008 · 74 citations · 22 references

DOI

Abstract

The results indicate that the LSS-induced VSMC migration and apoptosis are mediated by a downregulation of Rho-GDIalpha. The effect of Rho-GDIalpha on VSMC migration is mediated by the PI3K/Akt pathway, but its effect on VSMC apoptosis is not.

References

22

Blue silver: A very sensitive colloidal Coomassie G‐250 staining for proteome analysis

Giovanni Candiano, Maurizio Bruschi, Luca Musante et al. · Electrophoresis · 2004 · 1.9K citations

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Mohamad Irani-Tehrani, William B. Kiosses, Elisabetta Dejana et al. · Nature · 2005 · 1.2K citations

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Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

Gregory R. Hoffman, Nicolas Nassar, Richard A. Cerione · Cell · 2000 · 491 citations

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Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells

Stefanie Dimmeler, Corinna Hermann, Judith Haendeler et al. · Circulation Research · 1998 · 431 citations

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

Sivaramaprasad Gudi, John P. Nolan, John A. Frangos · Proceedings of the National Academy of Sciences · 1998 · 340 citations · Full text