Response criteria for phase II studies of supratentorial malignant glioma.

David R. Macdonald, T L Cascino, S. Clifford Schold, +1

Journal of Clinical Oncology

Tumor InnervationOncologic ImagingPet-mriHigh-grade GliomasBrain Lesion +18

Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma

Michael B. Atkins, Manuel Hidalgo, Walter M. Stadler, +9

Journal of Clinical Oncology

UrologyAdvanced Rcc PatientsGenitourinary CancerMedicineMetronomic Therapy +13

PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

Justin S. Smith, Issei Tachibana, Sandra Passe, +9

JNCI Journal of the National Cancer Institute

Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo

PS Departments

PathologyHigh-grade GliomasPi3k Path WayGliomaTumor Biology +14

AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression

Joseph Gera, Ingo K. Mellinghoff, Yijiang Shi, +5

Journal of Biological Chemistry

Akt ActivityC-myc ExpressionCyclin D1ImmunologyMammalian Target +15

Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.

Viktor Grünwald, Linda A. deGraffenried, Douglas Russel, +3

PubMed

Molecular PharmacologyUrologyChemoprevention StrategyMedicineProstate Cancer Cells +12

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.

Gheeyoung Choe, Steve Horvath, Timothy F. Cloughesy, +6

PubMed

Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.

Birgit Geoerger, Karol Kerr, Cong Tang, +5

PubMed

OncologyAntitumor ActivityGliomaRapamycin Analog Cci-779Single Agent +13

Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.

Tetsuro Sano, Huai Lin, Xiashan Chen, +8

PubMed

Mmac/pten ExpressionPathologyHigh-grade GliomasCancer BiologyGlioma +16

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

Jeffrey S. Eshleman, Brett L. Carlson, Ann C. Mladek, +3

PubMed

Tumor BiologyMammalian TargetRadiation MedicineRadiation TherapyGlioma +11