Concepedia

Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor

Jasminder Sahi, Mark A. Milad, Xianxian Zheng, Kelly Rose, Hongbing Wang, Linda Stilgenbauer, Darryl Gilbert, Summer Jolley, Ralph H. Stern, Edward L. LeCluyse

Journal of Pharmacology and Experimental Therapeutics · 2003 · 70 citations · 24 references

DOI

Concepts

References

24

Casarett and Doull's Toxicology: The Basic Science of Poisons

Annals of Internal Medicine · 1992 · 3.3K citations

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Bernd Greiner, Michel Eichelbaum, Péter Fritz et al. · Journal of Clinical Investigation · 1999 · 920 citations · Full text

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SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

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Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Anke Geick, Michel Eichelbaum, Oliver Burk · Journal of Biological Chemistry · 2001 · 841 citations · Full text

, , +12