MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE ^−/− Mice

Abstract

These data demonstrate that miR-33 deficiency serves to raise HDL-C, increase cholesterol efflux from macrophages via ABCA1 and ABCG1, and prevent the progression of atherosclerosis. Many genes are altered in miR-33-deficient mice, and detailed experiments are required to establish miR-33 targeting therapy in humans.