Concepedia

Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: The HIV-1 CD4:gp120 paradigm

Mattan Hurevich, Avi Swed, Salim Joubran, Shira Cohen, Noam S. Freeman, Elena Britan‐Rosich, Laurence Briant-Longuet, Martine Bardy, Christian Devaux, Moshe Kotler,

Bioorganic & Medicinal Chemistry · 2010 · 13 citations · 21 references

DOI

Concepts

References

21

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Peter D. Kwong, Richard T. Wyatt, James E. Robinson et al. · Nature · 1998 · 3K citations · Full text

, , +12

N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

, , +5

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

J Michael Kilby, Sam Hopkins, Thomas M. Venetta et al. · Nature Medicine · 1998 · 994 citations

, , +16

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

J S Kimpton, Michael Emerman · Journal of Virology · 1992 · 916 citations · Full text

, , +16

Energetics of the HIV gp120-CD4 binding reaction

David G. Myszka, Raymond W. Sweet, Preston Hensley et al. · Proceedings of the National Academy of Sciences · 2000 · 420 citations

, , +17