Concepedia

Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients

Verena Gounden, Chantal van Niekerk, Tracy Snyman, Jaya A. George

AIDS Research and Therapy · 2010 · 124 citations · 27 references

Open access

References

27

Treatment for Adult HIV Infection

Scott M. Hammer, Michael S. Saag, Mauro Schechter et al. · JAMA · 2006 · 1K citations

Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients

Catia Marzolini, Amalio Telenti, Laurent A. Décosterd et al. · AIDS · 2001 · 831 citations

Treatment for Adult HIV Infection

Patrick Yéni, Scott M. Hammer, Martin Hirsch et al. · JAMA · 2004 · 736 citations

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

David W. Haas, Heather J. Ribaudo, Richard B. Kim et al. · PubMed · 2004 · 628 citations

The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity

Bryan A. Ward, J. Christopher Gorski, David R. Jones et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 591 citations