Concepedia

Physical incorporation of a single‐stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus

Sarah Radecke, Frank Radecke, Ingrid Peter, Klaus Schwarz

The Journal of Gene Medicine · 2005 · 79 citations · 21 references

DOI

Abstract

The experiment showed that ODNs are incorporated into a mammalian genome. This unravels one early repair step and also sets an unexpected example of genome dynamics possibly relevant to other ODN-based cell techniques.

References

21

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.5K citations

, , +14

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

Marina Cavazzana, Salima Hacein‐Bey, Geneviève de Saint Basile et al. · Science · 2000 · 2.6K citations

, , +21

Correction of the Mutation Responsible for Sickle Cell Anemia by an RNA-DNA Oligonucleotide

Allyson Cole-Strauss, Kyonggeun Yoon, Yufei Xiang et al. · Science · 1996 · 318 citations

Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera

Saghir Akhtar, Ryszard Kole, R. L. Juliano · Life Sciences · 1991 · 214 citations

, , +6

Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides

S G Spitzer, Fritz Eckstein · Nucleic Acids Research · 1988 · 145 citations · Full text

, , +11