Concepedia

Sildenafil Inhibits β-Adrenergic–Stimulated Cardiac Contractility in Humans

Barry A. Borlaug, Vojtěch Melenovský, Tricia Marhin, Patricia Fitzgerald, David A. Kass

Circulation · 2005 · 168 citations · 32 references

DOI

Abstract

PDE5A inhibition by sildenafil blunts systolic responses to beta-adrenergic stimulation. This finding supports activity of PDE5A in the human heart and its role in modifying stimulated cardiac function.

References

32

Clinical Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Left Ventricular Filling Pressures

Steve R. Ommen, R A Nishimura, C. P. Appleton et al. · Circulation · 2000 · 2.8K citations · Full text

Oral Sildenafil in the Treatment of Erectile Dysfunction

Irwin Goldstein, Tom F. Lue, Harin Padma-Nathan et al. · New England Journal of Medicine · 1998 · 2.1K citations

Assessment of Mitral Annulus Velocity by Doppler Tissue Imaging in the Evaluation of Left Ventricular Diastolic Function

Daewon Sohn, In-Ho Chai, Dongjun Lee et al. · Journal of the American College of Cardiology · 1997 · 1.6K citations

, , +10

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

Eiki Takimoto, Hunter C. Champion, Manxiang Li et al. · Nature Medicine · 2005 · 894 citations

, , +9

Pulsed Doppler echocardiographic determination of stroke volume and cardiac output: clinical validation of two new methods using the apical window.

Jannet F. Lewis, Lawrence C. Kuo, Jeanne G. Nelson et al. · Circulation · 1984 · 733 citations · Full text

, , +21