Green Chemistry · 2011 · 1.1K citations · 7 references
PharmacyMedicinal ChemistryDrug DiscoveryPharmaceutical ManufacturingPharmaceutical RegulationResidual SolventsSafer SolventsSolvent ExtractionEnvironmental Impact MitigationEnvironmental Impact Of SolventsGreen Solvent SelectionGreener Solvent SelectionLife Cycle Inventory ModelingSolvent Life Cycle AssessmentSolvent SelectionSolvent Use Management
Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:
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The E Factor: fifteen years on
Roger A. Sheldon · Green Chemistry · 2007 · 1.6K citations
Alan D. Curzons, David N. Mortimer, David J. C. Constable et al. · Green Chemistry · 2001 · 588 citations