Concepedia

Sildenafil Promotes Ischemia-Induced Angiogenesis Through a PKG-Dependent Pathway

Annamalai Senthilkumar, Ray D. Smith, Jayant Khitha, Neeraj K. Arora, Srikar Veerareddy, Will Langston, John H. Chidlow, Shayne C. Barlow, Xinjun Teng, Rakesh P. Patel,

Arteriosclerosis Thrombosis and Vascular Biology · 2007 · 89 citations · 27 references

DOI

Abstract

These data demonstrate that sildenafil therapy results in increased angiogenic activity through a PKG-dependent pathway that is independent of nitric oxide production or NOS activity and identify the angiogenic therapeutic potential of sildenafil for critical limb ischemia.

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