Combined Influence of <i>LDLR</i> and <i>HMGCR</i> Sequence Variation on Lipid-Lowering Response to Simvastatin

Abstract

We have identified a common LDLR 3-UTR haplotype that is associated with attenuated lipid-lowering response to simvastatin treatment. Response was further reduced in individuals with both LDLR and previously described HMGCR haplotypes. Previously identified racial differences in statin efficacy were partially explained by the greater prevalence of these combined haplotypes in blacks.