Concepedia

Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

Samar H. Ibrahim, Petra Hirsova, Kyoko Tomita, Steven F. Bronk, Nathan W. Werneburg, Stephen A. Harrison, Val S. Goodfellow, Harmeet Malhi, Gregory J. Gores

Hepatology · 2015 · 228 citations · 32 references

DOI

Abstract

During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10-bearing vesicles from hepatocytes, which are chemotactic for macrophages.

References

32

Tissue-based map of the human proteome

Mathias Uhlén, Linn Fagerberg, Björn M. Hallström et al. · Science · 2015 · 15.3K citations · Full text

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Clotilde Théry, Sebastián Amigorena, Graça Raposo et al. · Current Protocols in Cell Biology · 2006 · 5.7K citations

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Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Jeffrey D. Browning, Lidia S. Szczepaniak, Robert L. Dobbins et al. · Hepatology · 2004 · 3.6K citations

The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study

Leon A. Adams, James Lymp, Jenny St. Sauver et al. · Gastroenterology · 2005 · 2.9K citations · Full text

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Long‐term follow‐up of patients with NAFLD and elevated liver enzymes†‡

Mattias Ekstedt, Lennart Franzén, Ulrik Mathiesen et al. · Hepatology · 2006 · 2.3K citations