Concepedia

A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors

Daruka Mahadevan, Laurence Cooke, Christopher Riley, Rachel Swart, Brian W. Simons, Kimiko Della Croce, Lee Wisner, Marilena V. Iorio, Kishore Shakalya, Harinder S. Garewal,

Oncogene · 2007 · 278 citations · 28 references

Concepts

MedicineMolecular BiologyOncologyGastrointestinal OncologyMolecular OncologySignal TransductionGastrointestinal Stromal TumorsReceptor Tyrosine Kinase SignalingSignal Transduction In CancerTherapeutic ResistanceTumor-stroma InteractionsTyrosine Kinase InhibitorsKinase Domain MutationsPrimary Resistance To ImatinibResistance To Tyrosine Kinase InhibitorsTherapeutic Tyrosine Kinase InhibitorsTyrosine Kinase InhibitionTyrosine Kinase Inhibitor TherapyTyrosine Kinase Receptors

References

28

PROCHECK: a program to check the stereochemical quality of protein structures

Roman A. Laskowski, Malcolm W. MacArthur, D. S. Moss et al. · Journal of Applied Crystallography · 1993 · 24.6K citations

Life Sciences, Biochemistry, Bioinformatics +9

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.5K citations

Medicine, Genetics, Oncology +17

Two Hundred Gastrointestinal Stromal Tumors

Ronald P. DeMatteo, Jonathan J. Lewis, Denis H. Y. Leung et al. · Annals of Surgery · 2000 · 2.5K citations · Full text

Medicine, Oncology, Surgery +15

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

Medicine, Genetics, Oncology +17

Enhanced genome annotation using structural profiles in the program 3D-PSSM 1 1Edited by J. Thornton

Lawrence A. Kelley, Robert M. MacCallum, Michael J.E. Sternberg · Journal of Molecular Biology · 2000 · 1.5K citations

Life Sciences, Bioinformatics, Biology +15