Quantitative analysis of ibuprofen in pharmaceutical formulations through FTIR spectroscopy

Abstract

The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablet form. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the infrared band corresponding to the carbonyl group centered at 1721.5 cm -1 . The specificity, linearity, detection limits, precision and accuracy of the calibration curve, ibuprofen extraction, infrared analysis and data manipulation were determined in or- der to validate the method. Moreover, the statis- tical results were compared with the quantifica- tion of ibuprofen through UV detection. The recovery values obtained in the analysis of pharmaceuticals are within the 98-110 % range.