γ371 Thr→Ile substitution in the fibrinogen γD domain causes hypofibrinogenaemia

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.1K citations

Engineering, Dna Analysis, Molecular Biology +19

The Molecular Basis of Blood Diseases.

Annals of Internal Medicine · 1987 · 635 citations · Full text

Functional Genomics, Disease Mechanism, Human Diseases +15

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin

Glen Spraggon, Stephen J. Everse, Russell F. Doolittle · Nature · 1997 · 390 citations

Fragment D, Crystal Structure, Protein Assembly +12

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency.

Yu‐Ling Wu, I. P. Whitman, Ernesto P. Molmenti et al. · Proceedings of the National Academy of Sciences · 1994 · 291 citations · Full text

Common Er Degradation, Immunology, Pathology +18

A simple method for DNA purification from peripheral blood

Thomas A. Ciulla, R. Sklar, Stephen L. Hauser · Analytical Biochemistry · 1988 · 229 citations

Dna Purification, Engineering, Molecular Biological Method +9