Single‐Molecule Protein Encapsulation in a Rigid DNA Cage

Abstract

Behind bars: A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60-kDa globular protein (Mr of cytochrome c: 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug-delivery system. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603392_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.