Autoregulation of 5-fluorouracil metabolism

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

Glen D. Heggie, Jean‐Pierre Sommadossi, David S. Cross et al. · PubMed · 1987 · 731 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

Barry Harris, Seng-Jaw Soong, Robert B. Diasio · PubMed · 1990 · 445 citations

Medicine, Pharmacokinetics, Pharmacology +17

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

Zhihong Lu, Ruiwen Zhang, Robert B. Diasio · PubMed · 1993 · 374 citations

Medicine, Oncology, Pharmacology +14

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

Xiaoxiong Wei, Howard L. McLeod, J McMurrough et al. · Journal of Clinical Investigation · 1996 · 360 citations · Full text

Life Sciences, Genetics, Oncology +17