Concepedia

N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

Xiaowen Mao, Tingting Wang, Yanan Liu, Michael G. Irwin, Jing‐Song Ou, Xiaolong Liao, Xia Gao, Yuan Xu, Kwok Fu Jacobus Ng, Paul M. Vanhoutte,

PLoS ONE · 2013 · 65 citations · 49 references

DOIFull text

Open access

Abstract

NAC and ALP confer synergistic cardioprotection in diabetes via restoration of cardiac HIF-1α and HO-1 signaling.

References

49

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

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, , +11

Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury

Zheqing Cai, Dominador J. Manalo, Wei Guo et al. · Circulation · 2003 · 550 citations · Full text

Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes

Marí-Carmen Desco, Miguel Asensi, Rafael Márquez et al. · Diabetes · 2002 · 388 citations · Full text

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Occurrence of oxidative stress during reperfusion of the human heart.

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HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

Ramzi Ockaili, Ramesh Natarajan, Fadi N. Salloum et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2005 · 212 citations