Concepedia

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

Lilly Xu, Yuping Chen, Yvonne Pan, Gary L. Skiles, Magang Shou

Drug Metabolism and Disposition · 2009 · 81 citations · 56 references

DOI

Concepts

References

56

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

, , +17

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

, , +17

A potentially hazardous interaction between erythromycin and midazolam

Klaus T. Olkkola, Kari Aranko, Harri Luurila et al. · Clinical Pharmacology & Therapeutics · 1993 · 354 citations

, , +13

An In Vitro Model for Predicting In Vivo Inhibition of Cytochrome P450 3A4 by Metabolic Intermediate Complex Formation

David R. Jones, Stephen D. Hall · Drug Metabolism and Disposition · 2000 · 294 citations

, , +17

Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations*

Teemu Kantola, Kari T. Kivistö, Pertti J. Neuvonen · Clinical Pharmacology & Therapeutics · 1998 · 283 citations

, , +13