Angewandte Chemie International Edition · 2008 · 123 citations · 21 references
Life SciencesBiochemistryBiotechnologyEnzyme TechnologyEnzymologyPolymer ChemistryEnzymatic BiosensorsEnzyme ImagingEnzyme-substrate RecognitionFluorescence SpectroscopySingle-molecule DetectionSingle-molecule ImagingEnzymesFluorescence-based Single-molecule DetectionFluorescent LabelsFluorescent PolymersFluorescent ProbesSingle-molecule Enzyme AssaysSingle-molecule EnzymologySingle-molecule Fluorescence Imaging
All in one: Exceptionally photostable, highly fluorescent, water-soluble, and monofunctional perylene and terrylene dyes bearing reactive groups for covalent attachment to biomolecules have been synthesized (see picture). Single-molecule enzyme tracking revealed that single enzymes could be visualized even on a substrate with fluorescent background.
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Taekjip Ha, Th. Enderle, D. Frank Ogletree et al. · Proceedings of the National Academy of Sciences · 1996 · 1.3K citations
Real-Time Single-Molecule Imaging of the Infection Pathway of an Adeno-Associated Virus
Georg Seisenberger, Martin U. Ried, Thomas Endreß et al. · Science · 2001 · 832 citations