Expression of an <i>ASCL2</i> related stem cell signature and <i>IGF2</i> in colorectal cancer liver metastases with 11p15.5 gain

Abstract

With unprecedented resolution a striking conservation of genomic alterations was demonstrated in liver metastases, suggesting that metastasis typically occurs after the pCRC has fully matured. In addition, we characterised a subset of liver metastases with an ASCL2-related stem-cell signature likely to affect metastatic behaviour of tumour cells.