Concepedia

PspC, a Pneumococcal Surface Protein, Binds Human Factor H

Sandhya Dave, Alexis Brooks-Walter, Michael K. Pangburn, Larry S. McDaniel

Infection and Immunity · 2001 · 214 citations · 15 references

DOIFull text

Open access

Concepts

Abstract

PspC was found to bind human complement factor H (FH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds FH very strongly. The binding of FH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.

References

15

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1977 · 684 citations · Full text

, , +14

Contribution of novel choline‐binding proteins to adherence, colonization and immunogenicity of <i>Streptococcus pneumoniae</i>

Carsten Rosenow, Patricia Ryan, Jeffrey N. Weiser et al. · Molecular Microbiology · 1997 · 487 citations · Full text

, , +17

SpsA, a novel pneumococcal surface protein with specific binding to secretory Immunoglobulin A and secretory component

Sven Hammerschmidt, Susanne R. Talay, Per Brandtzæg et al. · Molecular Microbiology · 1997 · 336 citations · Full text

, , +14

Pneumococcal Surface Protein A Inhibits Complement Activation by<i>Streptococcus pneumoniae</i>

Anh-Hue Thi Tu, Robert L. Fulgham, Mark A. McCrory et al. · Infection and Immunity · 1999 · 287 citations · Full text

, , +17

Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae

Marilyn J. Crain, W. D. Waltman, Jennifer S. Turner et al. · Infection and Immunity · 1990 · 268 citations · Full text

, , +9