Radiosensitization by Pan ErbB Inhibitor CI-1033 <b> <i>in Vitro</i> </b> and <b> <i>in Vivo</i> </b>

Abstract

These findings suggest that CI-1033 can increase the effectiveness of radiation therapy. The extent of suppression of tyrosine kinase activity by CI-1033, rather than the amount of activity in untreated cells, seemed to be more closely associated with the efficacy of combination treatment.