Concepedia
Cancer Letters · 2005 · 34 citations · 21 references
Life SciencesGeneticsMolecular BiologyEnzymologyGene ExpressionMetabolismEnzyme FunctionProlyl Hydroxylase Regulation
21
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations
Life Sciences, Cell Biology, Molecular Biology +17
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation
Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations
Life Sciences, Biochemistry, Molecular Biology +17
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing
Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text
Life Sciences, Biochemistry, Molecular Biology +16
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text
Life Sciences, Genetics, Molecular Biology +9
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
Richard K. Bruick, Steven L. McKnight · Science · 2001 · 2.5K citations