Functional and Biochemical Alterations of the Medial Frontal Cortex in Obsessive-Compulsive Disorder

Abstract

Hyperactivation of the MFC during high- vs low-conflict conditions in patients with OCD may be a compensatory response to a neuronal abnormality in the region. This relationship may partly explain the nature of inhibitory control deficits that are frequently seen in this group and may serve as a focus of future treatment studies.