Concepedia

Prefrontal Cortex Dysfunction

Prefrontal Cortex Dysfunction is a neurobiological construct referring to impaired regulatory functions of the prefrontal cortex, particularly in executive control, decision-making, and inhibitory processes, that underlies maladaptive behaviors in addiction by disrupting top-down modulation of limbic and reward-related brain circuits.

3K

Publications

289.7K

Citations

13.1K

Authors

2.6K

Institutions

Publications per year

2017–2026

747

Parents

Publications

3K

Insensitivity to future consequences following damage to human prefrontal cortex

Antoine Bechara, António R. Damásio, Hanna Damásio et al. · Cognition · 1994 · 6.1K citations

, , +8

Subgenual prefrontal cortex abnormalities in mood disorders

Wayne C. Drevets, Joseph L. Price, Joseph R. Simpson et al. · Nature · 1997 · 2.7K citations

, , +14

Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions

Antoine Bechara, Daniel Tranel, Hanna Damásio · Brain · 2000 · 1.9K citations

, , +16

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Bita Moghaddam, Barbara W. Adams, Anita Verma et al. · Journal of Neuroscience · 1997 · 1.8K citations · Full text

, , +14

Impairment of social and moral behavior related to early damage in human prefrontal cortex

Steven W. Anderson, Antoine Bechara, Hanna Damásio et al. · Nature Neuroscience · 1999 · 1.5K citations

, , +16

1–5 of 3K

Authors

13.1K

  1. TW
    Trevor W. Robbins

    University of Cambridge, United Kingdom

    46 publications · 7.9K citations

    34

    h-index

  2. AB
    Antoine Bechara

    University of Southern California, United States

    30 publications · 17.2K citations

    26

    h-index

  3. ND
    Nora D. Volkow

    Brookhaven National Laboratory, United States

    22 publications · 4.5K citations

    21

    h-index

  4. MN
    Marc N. Potenza

    Yale University, United States

    23 publications · 1.6K citations

    20

    h-index

  5. DT
    Daniel Tranel

    University of Iowa, United States

    20 publications · 8K citations

    19

    h-index

1–5 of 13.1K

Institutions

2.6K

  1. Yale University

    New Haven, United States

    61 h-index

    427 publications

    56.2K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    50 h-index

    296 publications

    44.8K citations

  3. University of Pittsburgh

    Pittsburgh, United States

    43 h-index

    257 publications

    26.3K citations

  4. National Institutes of Health

    Bethesda, United States

    42 h-index

    212 publications

    25K citations

  5. Harvard University

    Cambridge, United States

    41 h-index

    221 publications

    49.6K citations

  6. National Institute of Mental Health

    Bethesda, United States

    39 h-index

    163 publications

    33.7K citations

  7. University of Iowa

    Iowa City, United States

    38 h-index

    109 publications

    66.8K citations

  8. King's College London

    London, United Kingdom

    37 h-index

    199 publications

    16.9K citations

1–8 of 2.6K

Venues

  1. Biological Psychiatry

    87 publications · 15.3K citations

    62

    h-index

  2. Journal of Neuroscience

    83 publications · 18.7K citations

    60

    h-index

  3. American Journal of Psychiatry

    65 publications · 14.6K citations

    54

    h-index

  4. Neuropsychopharmacology

    83 publications · 9.5K citations

    50

    h-index

  5. Psychopharmacology

    63 publications · 4.8K citations

    38

    h-index

1–5