Science · 1999 · 251 citations · 18 references
Life SciencesCell BiologyDermatologyApoptosisCell SignalingDna RepairApoptosis RegulationApoptotic SignalingDna DamageDna Damage SignalingDna Damage-induced ApoptosisUltraviolet Radiation BiologyDna Damage SensorsFas LigandFas Ligand-mediated ApoptosisKeratinocyte BiologyP53 MutationPro-apoptotic ProteinsUltraviolet Radiation DamageUltraviolet-induced Dna Damage
DNA-damaged cells can either repair the DNA or be eliminated through a homeostatic control mechanism termed "cellular proofreading." Elimination of DNA-damaged cells after ultraviolet radiation (UVR) through sunburn cell (apoptotic keratinocyte) formation is thought to be pivotal for the removal of precancerous skin cells. Sunburn cell formation was found to be dependent on Fas ligand (FasL), a pro-apoptotic protein induced by DNA damage. Chronic exposure to UVR caused 14 of 20 (70 percent) FasL-deficient mice and 1 of 20 (5 percent) wild-type mice to accumulate p53 mutations in the epidermis. Thus, FasL-mediated apoptosis is important for skin homeostasis, suggesting that the dysregulation of Fas-FasL interactions may be central to the development of skin cancer.
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Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Thomas S. Griffith, Thomas Brunner, Sharon M. Fletcher et al. · Science · 1995 · 2K citations
Medicine, Immunology, Ophthalmology +17
Sunburn and p53 in the onset of skin cancer
Annemarie Ziegler, Alan S. Jonason, David J. Leffellt et al. · Nature · 1994 · 1.5K citations
Medicine, Dermatology, Oncology +12